First Year Computer Science Projects at Coventry University:Activity-led integrative team projects with continuous assessment.

We describe the group projects undertaken by first year undergraduate Computer Science students at Coventry University. These are integrative course projects: designed to bring together the topics from the various modules students take, to apply them as a coherent whole. They follow an activity-led approach, with students given a loose brief and a lot of freedom in how to develop their project. We outline the new regulations at Coventry University which eases the use of such integrative projects. We then describe our continuous assessment approach: where students earn a weekly mark by demonstrating progress to a teacher as an open presentation to the class. It involves a degree of self and peer assessment and allows for an assessment of group work that is both fair, and seen to be fair. It builds attendance, self-study / continuous engagement habits, public speaking / presentation skills, and rewards group members for making meaningful individual contributions.Comment: 4 pages. Accepted for presentation at CEP2

Towards a machine-independent transput section

If the transput section of an ALGOL-68 compiler is to be portable, it must be described in such a way that it is clear which aspects are machine-dependent, and which are not. There should be a clear set of primitives underlying the transput. In this report, a description is proposed which can really be used as an implementation model: the transput is described in pseudo-ALGOL 68, except for the underlying primitives, whose semantics are given in some kind of formalized English. The state of this model is by no means definitive, but may serve as a start for further discussion

Measurement of the Charged Multiplicities in b, c and Light Quark Events from Z0 Decays

Average charged multiplicities have been measured separately in $b$, $c$ and light quark ($u,d,s$) events from $Z^0$ decays measured in the SLD experiment. Impact parameters of charged tracks were used to select enriched samples of $b$ and light quark events, and reconstructed charmed mesons were used to select $c$ quark events. We measured the charged multiplicities: $\bar{n}_{uds} = 20.21 \pm 0.10 (\rm{stat.})\pm 0.22(\rm{syst.})$, $\bar{n}_{c} = 21.28 \pm 0.46(\rm{stat.}) ^{+0.41}_{-0.36}(\rm{syst.})$ $\bar{n}_{b} = 23.14 \pm 0.10(\rm{stat.}) ^{+0.38}_{-0.37}(\rm{syst.})$, from which we derived the differences between the total average charged multiplicities of $c$ or $b$ quark events and light quark events: $\Delta \bar{n}_c = 1.07 \pm 0.47(\rm{stat.})^{+0.36}_{-0.30}(\rm{syst.})$ and $\Delta \bar{n}_b = 2.93 \pm 0.14(\rm{stat.})^{+0.30}_{-0.29}(\rm{syst.})$. We compared these measurements with those at lower center-of-mass energies and with perturbative QCD predictions. These combined results are in agreement with the QCD expectations and disfavor the hypothesis of flavor-independent fragmentation.Comment: 19 pages LaTex, 4 EPS figures, to appear in Physics Letters

Whole-genome sequencing reveals host factors underlying critical COVID-19

Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care1 or hospitalization2,3,4 after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genes—including reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)—in critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease

Greetings from Harrisonburg, Va. The Old Spring

A postcard depicting the Old Spring in Harrisonburg, Virginia, 1904